[HTML][HTML] Srebp2: A master regulator of sterol and fatty acid synthesis1
BB Madison - Journal of lipid research, 2016 - ASBMB
334 Journal of Lipid Research Volume 57, 2016 transcript levels of Srebp1a and Srebp1c
(from the Srebpf1 locus) were dramatically reduced, which may be responsible for depletion
of fatty acid synthesis genes. This effect was also observed in the liver of a sole surviving
Srebf2−/− adult animal. This trend of reduced expression of Srebp1a and 1c was also
encountered in adult Srebf2–/hyp animals, albeit less severe. Unlike effects in the liver
caused by Srebp2 deficiency, in inguinal subcutaneous white adipose tissue (iWAT) …
(from the Srebpf1 locus) were dramatically reduced, which may be responsible for depletion
of fatty acid synthesis genes. This effect was also observed in the liver of a sole surviving
Srebf2−/− adult animal. This trend of reduced expression of Srebp1a and 1c was also
encountered in adult Srebf2–/hyp animals, albeit less severe. Unlike effects in the liver
caused by Srebp2 deficiency, in inguinal subcutaneous white adipose tissue (iWAT) …
